In the West, I'll go with Anaheim in six or seven. They knocked on the door last year, and should go further this year. As a former crappy defenseman in weak adult rec. leagues, I'm a huge fan of Niedermayer and Pronger. And I just don't care for the Wings...
In the East, I'll say Sens in seven because I'd like to see them do well after all the disappointments of the past decade. But logic (eg the above-cited "knocking on the door") does dictate Buffalo...
At any rate, we should have three excellent series coming up.
[Added 3 days later] Sens take first two games in Buffalo! Detroit won first game due to power play, despite mostly being outplayed.