uh...what kind of amp are you using?
For most gigs, I'm using a Boss GT-6 floor pedal as my preamp, into a Carvin dual channel power amp (yes, it's a tube amp), into a 2x12 cab wired for stereo. So yes, analog to digital to tube. The Boss is very convenient, but I admit that it doesn't sound as good as I would like. Not horrible to my ears, just not awesome. I won't be using it in the studio most likely, but it works well for the gigs we do.