Yeah. It's much easier if you have removable headshells, like the ones on Technics tables, or SME tonearms. OR if you have a separate table for mono records.
Even with removable headshells, don't forget that cartridges have different tracking forces, and different VTAs, which you'd need to tweak every time you change the headshells....unless you have, for example, two cartridges of identical dimensions, like 2 Grados, one mono, one stereo. Then the switch from stereo to mono would be effortless.
If not, having two turntables set up, for stereo and mono, is ideal. You'd only need to set it up each cartridge once.