Never run out of BP medication. That is the gospel truth. I hit 241/137 while on mine. The nurse practitioner at my doctor's office said, "let's monitor your pressure. Come back in a week" I was still hit those numbers. ended up finding myself a new doctor. My medications weren't working for me anymore. The new medication is working very well. Losartan/Hctz 12mg a day along with Metoprolo Tartrate 50 mg twice a day, Metoprolo I was already taking. I was taking lisinopril 40 mg a day. During the week I was monitoring, I double to 80 mg a day. That did nothing to help.