I think Eddie Condon's was, too, but they may have been on 54th St. by then! I dimly remember going to both Ryan's and Condon's (at least one for sure ); they were practically next door to each other iirc. I definitely recall Max Kaminsky hawking his LPs at the back of one of the clubs. As a NYC tourist in the late '70s-early '80s, I might have been naive, but regarded the 54th St. survivors as the last of "52nd St.".
I believe "52nd St. loosely interpreted" ended for good when a big new building went up in 1983 (?) and the (brownstone) bldgs housing the remaining clubs on 54th were demolished (as happened on 52nd in 1962, see Wiki citation below).
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Condon's opens @ 144 W 54 in 1975
1976 article on Ryan's, which moved to 154 W 54 in 1963.
According to Wikipedia, "52nd St." proper seems to have ended in 1962, though I'm never 100% sure of Wiki assertions.